Contact inhibition of locomotion and junctional mechanics guide collective cell behavior in epithelial wound repair
نویسندگان
چکیده
Affiliations: 1Institute of Complex Systems and Mathematical Biology, University of Aberdeen, United Kingdom; 2Centre for BioNano Interactions, School of Chemistry and Chemical Biology, University College Dublin, Belfield, Ireland; 3School of Physics, University College Dublin, Dublin, Ireland; and 4Institute for Molecular Bioscience, Division of Cell Biology and Molecular Medicine, The University of Queensland, St. Lucia, Brisbane, Queensland, Australia 4072
منابع مشابه
Re: Collective and single cell behavior in epithelial contact inhibition.
Control of cell proliferation is a fundamental aspect of tissue physiology central to morphogenesis, wound healing, and cancer. Although many of the molecular genetic factors are now known, the system level regulation of growth is still poorly understood. A simple form of inhibition of cell proliferation is encountered in vitro in normally differentiating epithelial cell cultures and is known a...
متن کاملContact inhibition of locomotion and mechanical cross-talk between cell–cell and cell–substrate adhesion determine the pattern of junctional tension in epithelial cell aggregates
We used a computational approach to analyze the biomechanics of epithelial cell aggregates-islands, stripes, or entire monolayers-that combines both vertex and contact-inhibition-of-locomotion models to include cell-cell and cell-substrate adhesion. Examination of the distribution of cell protrusions (adhesion to the substrate) in the model predicted high-order profiles of cell organization tha...
متن کاملModeling Contact Inhibition of Locomotion of Colliding Cells Migrating on Micropatterned Substrates
In cancer metastasis, embryonic development, and wound healing, cells can coordinate their motion, leading to collective motility. To characterize these cell-cell interactions, which include contact inhibition of locomotion (CIL), micropatterned substrates are often used to restrict cell migration to linear, quasi-one-dimensional paths. In these assays, collisions between polarized cells occur ...
متن کاملSingle cell gene expression analysis in injury-induced collective cell migration.
Collective cell behavior in response to mechanical injury is central to various regenerative and pathological processes. Using a double-stranded locked nucleic acid probe for monitoring real-time intracellular gene expression, we examined the spatiotemporal response of epithelial cells during injury-induced collective migration and compared to the blocker assay with minimal injury as control. W...
متن کاملFormin-mediated actin polymerization at cell–cell junctions stabilizes E-cadherin and maintains monolayer integrity during wound repair
Cadherin-mediated cell-cell adhesion is required for epithelial tissue integrity in homeostasis, during development, and in tissue repair. E-cadherin stability depends on F-actin, but the mechanisms regulating actin polymerization at cell-cell junctions remain poorly understood. Here we investigated a role for formin-mediated actin polymerization at cell-cell junctions. We identify mDia1 and Fm...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2017